The Leo Apostel Center in collaboration with the Doctoral Programme of the VUB invites everyone to the 40th of its interdisciplinary seminars in the Foundations series. In this series CLEA invites scholars that are actively engaged in the research on the foundations of a particular discipline. Their lectures will always be directed to an interdisciplinary audience, and the discussions aim at confronting the foundations of the different disciplines. Is Quantum Computation Relevant to the Brain? The Penrose-Hameroff 'Orch OR' model of Consciousness by Prof. Dr. Stuart Hameroff (Departments of Anesthesiology and Psychology, University of Arizona, Tucson, USA) Monday, August 23, 1999 at 5 p.m. in room 5/B 406 (building B, 5th floor) Vrije Universiteit Brussel, Campus Oefenplein About the lecture Enigmatic features of consciousness (e.g. nature of experience/"qualia", binding, pre-conscious to conscious transition, "non-computability", free will) suggest that reductionist/emergent approaches by themselves are insufficient to fully explain consciousness. Additional panexperiential/panproto-psychist approaches may be necessary in which the nature of experience ('qualia') and other enigmatic features derive from a fundamental (quantum) feature of reality, and "proto-conscious" qualia are intrinsic to nature, like mass, spin or charge. How could subtle quantum effects be linked to brain processes? The Penrose-Hameroff "Orch OR" model suggests that quantum superposition/quantum computation occur in protein microtubules within the brain's neurons. The quantum computation in microtubules (isolated from environmental decoherence by biological mechanisms) is suggested to proceed according to the Schrodinger equation until threshold is reached (after tens to hundreds of milliseconds) for "self-collapse" of the quantum wave function by the Penrose-proposed quantum gravity mechanism (objective reduction - "OR"). Outputs of each quantum computation chosen in the OR self-collapse are particular states of tubulins within microtubules which then govern neuronal activity including synaptic function. At a deeper level, each OR self-collapse is a self-organizing event in proto-conscious ("funda- mental") spacetime geometry. We suggest these events may be "conscious moments" (Whitehead "occasions of experience") occurring for example at 40 Hz. In the model, biological factors provide feedback to "orchestrate" the quantum computation in microtubules (orchestrated objective reduction---"Orch OR"). The Orch OR model is testable, and can potentially solve enigmatic features of consciousness. As quantum computation becomes technological reality, the brain/mind may inevitably be compared to a quantum computer. About the speaker Prof. Dr. Stuart Hameroff (l947) practices and teaches clinical anesthesiology at University Medical Center and does research into the mechanism of consciousness at the University of Arizona. He studied chemistry, physics and mathematics at the University of Pittsburgh. In 1973 he got his M.D. at the Hahnemann Medical College, Philadelphia. In the early 1990's he was strongly influenced by Roger Penrose's The Emperor's New Mind (and later Shadows of the Mind, Oxford Press, 1989 and 1994). In 1994 he co-organized an international, multidisciplinary conference "Toward a Scientific Basis for Consciousness" held at the University of Arizona. A book of selected papers from that conference (Toward a Science of Consciousness -The First Tucson Discussions and Debates, S Hameroff, A Kaszniak, A Scott, Eds., MIT Press/Bradford Books, Cambridge MA) was published in the spring of 1996. He began to formalize his efforts in a proposed "Center for Consciousness Studies" at the University of Arizona. The Tucson III conference was held in 1998 and selected papers are in the third book in the MIT Press series (with David Chalmers joining as co- editor) due out late 1999 or early 2000. The presentation with questions will last about an hour. Afterwards, an hour or more is reserved for an in-depth, group discussion of the topic. More info at the CLEA office: phone 02-644 26 77 or via the Web-page: http://pespmc1.vub.ac.be/CLEA/